Using Nero Back it up right now.
I used to use Ghost, I still have it, but I just wanted to try something different.
Please! For your sake, perform a test and make sure you can restore your data onto a new, blank hard drive. I've seen too many people be burned by backup software that they thought was protecting them, but whose restore function they never tested before they needed it. Then when they did need the restore function they found out it either didn't work at all or didn't work in the way they thought it would. At least two people have reported this problem with Nero's backup right here
Now, I am not bashing Nero in particular. Any backup strategy that hasn't been tested for its ability to properly restore the data is almost as bad as no backup at all. But I do have one beef with Nero's backup, and that is that there is no tool that will allow you to break open the backup and restore individual files if you use the full-disc backup option and it fails to restore the complete disc image. Nero really should let you restore individual data files from a full-disc backup even if something goes wrong and you can't restore the entire image onto a new hard drive.
Backup strategies aren't something to just change for the sake of trying something new, unless you really don't need to protect the data you are backing up anyway.