Yup, fresh windows install (seems to be a montly thing for me).
I'm not running Crossfire - I only have a single card. Just a Crossfire chipset mobo.
And yes, the mobo+cpu is the ONLY hardware that's changed.
I haven't tried from safe mode. I'll give that a shot here in a bit...
BenQ 1655, BenQ 1620, LG 4167, Plex PX-716SA, Samsung SH-S162L, SH-S182M, Pioneer 111D, Lite-On SHM-165H6S and 1.9TB of HDDs to feed 'em and an X2/4800 to crunch for 'em.