I was unable to back up a >4GB file onto a DVD-R or DVD+R today, using Nero 184.108.40.206 OEM. I finally figured out that Nero *STUPIDLY* writes the DVD with a Joliet filesystem, which does not support such large files. Consequently, the file cannot be read back in, which shows itself as a data verification failure. I see no way to convince Nero to write a UDF filesystem. (In fact, by the way, I see no way to convince Nero 220.127.116.11 OEM to bring up the old Nero Burning ROM program. Apparently that is now a retail-only feature.)
B's Recorder Gold 5.32 is only a little better: It gives an error message as soon as such a large file is chosen.
When I had Easy CD Creator 5.3.5 Basic, it was smart enough to notice the file's size and automatically write a UDF filesystem instead. Unfortunately, in the process of managing burn-software conflicts I uninstalled Easy CD Creator.
It is surprising that many people scorn Easy CD Creator, when it does the sensible thing whereas Nero's behavior is totally unreasonable.