Apart from the 4GB max file size limitation with FAT32, another major issue is the performance issue when a large partition is used; NTFS performance is not hindered by the size of the partition. While many benchmarks show FAT32 surpassing NTFS, they neglect to show the effect of FAT32 on a large hard drive. Personally, the performance issue is of little concern; the 4GB file limit of FAT32 is a deal-breaker for video-editing buffs.
Drives I Own:
Asus S520/A, Plextor UltraPlex 40TSi, Lite-on XJ-HD166S, Pioneer DVD-106S, Toshiba SD-M1712, Plextor PX-R820Ti, Plextor PX-W1210TS, Plextor Premium, Samsung SM-352B, Teac CD-W540E, Yamaha CRW-F1, Plextor PX-708A, Sony DRU-510A